930237

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

• Sinonimo/i: CANDDY_MLN Tag NHS ester
• Formula empirica (notazione di Hill): C₁₉H₂₁Cl₂N₃O₆
• Peso molecolare: 458.29
• Codice UNSPSC: 12352209
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: powder
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
• InChI: 1S/C19H21Cl2N3O6/c1-10(2)7-14(19(29)30-24-16(26)5-6-17(24)27)23-15(25)9-22-18(28)12-8-11(20)3-4-13(12)21/h3-4,8,10,14H,5-7,9H2,1-2H3,(H,22,28)(H,23,25)/t14-/m0/s1; KCUJPSDSTWVHLQ-AWEZNQCLSA-N

Descrizione

Applicazioni

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable