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47674

Sigma-Aldrich

Fmoc-Gln(Trt)-OH

≥98.0% (HPLC), for peptide synthesis

Sinonimo/i:

Nα-Fmoc-Nδ-trityl-L-glutamine

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5 G
47,20 €
25 G
120,00 €
100 G
364,00 €
1 KG
2.600,00 €

47,20 €


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5 G
47,20 €
25 G
120,00 €
100 G
364,00 €
1 KG
2.600,00 €

About This Item

Formula empirica (notazione di Hill):
C39H34N2O5
Numero CAS:
Peso molecolare:
610.70
Beilstein:
4343953
Numero MDL:
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
NACRES:
NA.26

47,20 €


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Nome del prodotto

Fmoc-Gln(Trt)-OH, ≥98.0% (HPLC)

Livello qualitativo

Saggio

≥98.0% (HPLC)

Stato

powder

Attività ottica

[α]/D -14.0±1.5°, c = 1% in DMF

Impiego in reazioni chimiche

reaction type: Fmoc solid-phase peptide synthesis

applicazioni

peptide synthesis

Gruppo funzionale

Fmoc

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)[C@H](CCC(=O)NC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46

InChI

1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1
WDGICUODAOGOMO-DHUJRADRSA-N

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Descrizione generale

Fmoc-Gln(Trt)-OH also known as Nα-Fmoc-Nδ-trityl-L-glutamine, a Fmoc protected amino acid derivative used as a reagent in the synthesis of peptides. As glutamine is protected with a trityl group, unwanted substitute products in the reactions can be prevented. [1]

Applicazioni

Fmoc-Gln(Trt)-OH is used as a starting material in the Fmoc solid phase peptide synthesis of fellutamide B and N-octanoyl analog of fellutamide B. [2]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Protection of carboxamide functions by the trityl residue. Application to peptide synthesis
P Sieber, et.al.
Tetrahedron Letters, 32, 739-742 (1991)
Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog
JS Schneekloth
Bioorganic & Medicinal Chemistry Letters, 16, 3855-3858 (2006)
Cathleen Jendrny et al.
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Serpin proteins irreversibly inhibit serine proteases, but only a small part of the serpin reactive-center loop (RCL) is responsible for the initial protein-protein interaction (PPI). To develop peptidic protease inhibitors, kallikrein-related peptidases 7 (KLK7) and 5 (KLK5) were chosen. Firstly
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In this paper, a self-delivery chimeric peptide PpIX-PEG8 -KVPRNQDWL is designed for photodynamic therapy (PDT) amplified immunotherapy against malignant melanoma. After self-assembly into nanoparticles (designated as PPMA), this self-delivery system shows high drug loading rate, good dispersion, and stability as

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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