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333662

Sigma-Aldrich

1H-1,2,3-Triazole

97%

Sinonimo/i:

2,3-Diazapyrrole, 2H-1,2,3-Triazole, Osotriazole, Pyrrodiazole, Triazacyclopentadiene

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About This Item

Formula empirica (notazione di Hill):
C2H3N3
Numero CAS:
288-36-8
Peso molecolare:
69.07
Numero MDL:
MFCD00014490
Codice UNSPSC:
12352100
ID PubChem:
24860165
NACRES:
NA.22

Saggio

97%

Forma fisica

liquid

Indice di rifrazione

n20/D 1.498 (lit.)

P. eboll.

203 °C/752 mmHg (lit.)

Punto di fusione

23-25 °C (lit.)

Densità

1.192 g/mL at 25 °C (lit.)

Stringa SMILE

c1c[nH]nn1

InChI

1S/C2H3N3/c1-2-4-5-3-1/h1-2H,(H,3,4,5)
QWENRTYMTSOGBR-UHFFFAOYSA-N

Categorie correlate

Descrizione generale

2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.

Applicazioni

  • Crystalline framework materials: Research on triazole carboxylic acid ligand has demonstrated its application in smart crystalline framework materials, notably for fluorescence sensing and catalytic reduction of p-nitrophenol, illustrating its utility in chemical sensing and environmental applications (Lv et al., 2023).
  • PXR receptor modulation: 1H-1,2,3-Triazole-4-carboxamides have been optimized as potent and selective inverse agonists and antagonists of the PXR receptor, providing insights into the design of receptor-specific drugs (Li et al., 2022).
  • Large-scale synthesis: The large-scale synthesis of a Notum inhibitor employing a modified Sakai reaction illustrates the importance of 1H-1,2,3-triazole in the production of biochemical reagents, which can be essential in medical research and drug development (Atkinson et al., 2022).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

224.6 °F - closed cup

Punto d’infiammabilità (°C)

107 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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1,2,4-Triazole-3-carboxylic acid 97%

Sigma-Aldrich

658472

1,2,4-Triazole-3-carboxylic acid

Methyl-1H-1,2,4-triazole-3-carboxylate 98%

Sigma-Aldrich

530352

Methyl-1H-1,2,4-triazole-3-carboxylate

2-(2,4,6-TRICHLOROPHENOXY)PROPIONIC ACID AldrichCPR

S365211

2-(2,4,6-TRICHLOROPHENOXY)PROPIONIC ACID

Zhen Zhou et al.
Journal of the American Chemical Society, 127(31), 10824-10825 (2005-08-04)
We report 1H-1,2,3-triazole as an active group to dramatically enhance proton conduction in a polymer electrolyte membrane (PEM). The conductivities of a poly(4-vinyl-1H-1,2,3-triazole) membrane without any acidic dopants are about 105 times greater than those of poly(4-vinylimidazole) in dry air
Atul Bhardwaj et al.
Nature communications, 8(1), 1-1 (2017-02-25)
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases. The amino-acid sequence and structural similarity between inducible cyclooxygenase-2 and housekeeping cyclooxygenase-1 isoforms present a significant challenge to
Amanda R Robinson et al.
PLoS pathogens, 8(2), e1002516-e1002516 (2012-02-22)
The Epstein-Barr virus (EBV) latent-lytic switch is mediated by the BZLF1 immediate-early protein. EBV is normally latent in memory B cells, but cellular factors which promote viral latency specifically in B cells have not been identified. In this report, we
Fong-Fong Chu et al.
World journal of gastroenterology, 22(46), 10158-10165 (2016-12-29)
To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium (S. Tm) in a mouse model. Eight-week-old male wild-type (WT) and Nox1 knockout (KO) C57BL6/J (B6) mice were administered metronidazole water for 4 d to
Paco Pino et al.
PLoS pathogens, 3(8), e115-e115 (2007-09-06)
Toxoplasma gondii is an aerobic protozoan parasite that possesses mitochondrial antioxidant enzymes to safely dispose of oxygen radicals generated by cellular respiration and metabolism. As with most Apicomplexans, it also harbors a chloroplast-like organelle, the apicoplast, which hosts various biosynthetic
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