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Merck

TRPV4

transient receptor potential cation channel, subfamily V, member 4

Sinonimi:
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Specie:
ID UniProtKB:
ID gene:
  • Human(59341) Summary: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
  • Mouse(63873) transient receptor potential cation channel, subfamily V, member 4
  • Rat(66026) transient receptor potential cation channel, subfamily V, member 4
  • naked mole-rat(101706710) transient receptor potential cation channel, subfamily V, member 4
  • domestic guinea pig(100724607) transient receptor potential cation channel, subfamily V, member 4
  • sheep(101113534) transient receptor potential cation channel, subfamily V, member 4
  • domestic cat(101084907) transient receptor potential cation channel, subfamily V, member 4
  • Horse(100066552) transient receptor potential cation channel, subfamily V, member 4
  • cow(540259) transient receptor potential cation channel, subfamily V, member 4
  • chicken(395427) transient receptor potential cation channel, subfamily V, member 4
  • dog(486308) transient receptor potential cation channel, subfamily V, member 4
  • Zebrafish(557850) transient receptor potential cation channel, subfamily V, member 4

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Specie
rat, human
N-Vanillylnonanamide, ≥97%, powder,
Specie
rat

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
Capsazepine, ≥98% (HPLC), solid,
Specie
human, rat
Capsaicin, ≥95%, from Capsicum sp.,
Specie
rat, human
Capsaicin, natural,
Specie
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Specie
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Specie
human, rat, mouse

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-TRPV4 Antibody, clone 1G10-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
canine, human, mouse, rat
Applicazione
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anticorpo anti-Trpv4, clone 1B2.6, clone 1B2.6, from mouse,
Reattività con
human, mouse
Applicazione
immunocytochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reattività con
rat
Applicazione
western blot
Anti-Transient Receptor Potential Vanilloid 4 Antibody, pain, Chemicon®, from rabbit,
Reattività con
rat
Applicazione
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, rabbit
Applicazione
immunohistochemistry
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
Butamben, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Capsaicin, ≥95%, from Capsicum sp.,
Specie
rat, human
Capsaicin, natural,
Specie
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Specie
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Specie
human, rat, mouse

Small Molecule - Mixed Agonist/Antagonist

N° Catalogo
Descrizione
Specie
N-Vanillylnonanamide, ≥97%, powder,
Specie
rat
Capsazepine, ≥98% (HPLC), solid,
Specie
human, rat

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting mouse Trpv4,
Specie
mouse
MISSION® esiRNA, targeting human TRPV4,
Specie
human