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Merck

PRKCA

protein kinase C, alpha

Sinonimi:
AAG6, PKC-alpha, PKCA, PRKACA
Specie:
Human PRKCA (5578), Mouse Prkca (18750), Rat Prkca (24680), Horse PRKCA (100063318), dog PRKCA (490904), Domestic Rabbit PRKCA (100037720), domestic cat PRKCA (101086433), sheep PRKCA (101110074), Zebrafish prkca (497384), chicken PRKCA (417430) ...Più
ID UniProtKB:
P17252, B5BU22, Q15137, Q32M72, Q96RE4
ID gene:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

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Small Molecule - Activator

N° Catalogo
Descrizione
Specie
20-133-M
PKC Lipid Activator, ,
Specie
human

Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
O1008
Acido oleico, ≥99% (GC),
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
SAB4502354
Anti-PKC α antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
SAB4502356
Anti-PKC-PAN antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB4200739
Anti-Protein kinase C antibody, Mouse monoclonal, clone MC5, purified from hybridoma cell culture,
Reattività con
bovine, chicken, fish, human, mouse, rabbit, rat
Applicazione
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
western blot
05-983
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
07-790
Anti-phospho-PKCα (Ser657/Tyr658) Antibody, Upstate®, from rabbit,
Reattività con
human, rabbit, rat
Applicazione
ELISA
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
S7049
D-Sphingosine, synthetic,
Specie
rat
O6754
1-Oleoyl-2-acetyl-sn-glycerol, ≥97% (TLC), oil,
Specie
human
K1639
K-252a, from Nonomuraea longicatena, ≥98% (HPLC),
Specie
rat, human
K2015
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
Specie
rat, human
C9911
(S)-(+)-Camptothecin, ≥90% (HPLC), powder,
Specie
rat, mouse, human

Proteins

N° Catalogo
Descrizione
Specie
14-484-M
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Specie
human
P1782
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Specie
human
SRP5251
PKC-α, active, GST tagged from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie

esiRNA

N° Catalogo
Descrizione
Specie
EMU080561
MISSION® esiRNA, targeting mouse Prkca,
Specie
mouse
EHU050821
MISSION® esiRNA, targeting human PRKCA,
Specie
human

Small Molecule - Substrate

N° Catalogo
Descrizione
Specie
12-123
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
Specie
human
20-131
PKC Substrate Cocktail, ,
Specie
human