SML2694

FB23-2

≥98% (HPLC), m6A demethylase inhibitor, powder

• Szinonimák: 2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxybenzamide
• Tapasztalati képlet (Hill-képlet): C₁₈H₁₅Cl₂N₃O₃
• CAS-szám: 2243736-45-8
• Molekulatömeg: 392.24
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Termék neve: FB23-2, ≥98% (HPLC)
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: white to beige
• oldhatóság: DMSO: 2 mg/mL, clear
• tárolási hőmérséklet: 2-8°C
• SMILES string: ClC1=C(NC2=C(C(NO)=O)C=CC=C2)C(Cl)=CC(C3=C(C)ON=C3C)=C1
• InChI: 1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
• Nemzetközi kémiai azonosító kulcs: ILHNIWOZZKIBNW-UHFFFAOYSA-N

Leírás

Biokémiai/fiziológiai hatások

FB23-2 can also prevent osteogenic differentiation of human mesenchymal stem cells (MSCs). It is capable of delaying leukemogenesis in vivo. In mice, FB23-2 at a dose of 20 mg/kg is safe for testing in vivo efficacy.

FB23-2 is a cell penetrant, potent and specific inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein) that RNA methylation in varies of AML cells. FB23-2 potently inhibits proliferation and promotes apoptosis and differentiation in human acute myeloid leukemia (AML) cells and primary blast AML cells lines and xenografts in mice. It minimally affects proliferation of human normal bone marrow cells.

cell penetrant, potent and specific inhibitor of N6-methyladenosine (m6A) demethylase FTO

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable