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Merck
Összes fotó(2)

Fontos dokumentumok

354-05A

Sigma-Aldrich

Human Aortic Smooth Muscle Cells: HAOSMC, adult

Szinonimák:

HAOSMC cells

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

UNSPSC kód:
41106514
NACRES:
NA.81

biológiai forrás

human aorta (normal, tunica intima and tunica media, fibrous plaque-free)

Minőségi szint

100

kiszerelés

pkg of 500,000 cells

gyártó/kereskedő neve

Cell Applications, Inc

növekedési mód

Adherent

kariotípus

2n = 46

morfológia

smooth muscle

technika/technikák

cell culture | mammalian: suitable

vonatkozó betegség(ek)

cardiovascular diseases

kiszállítva

dry ice

tárolási hőmérséklet

−196°C

Általános leírás

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

Human Aortic Smooth Muscle Cells (HAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.

HAOSMC have been utilized in dozens of research studies, for example, to:elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function (Liu, 2009; Tan, 2009; Seymour, 2010; Chen, 2011; Hirase, 2013; Stein, 2013):
  • Understand hyperglycemia-related risk factors for atherosclerosis in diabetes patients (Maier, 2010), as well as effects of ethanol on vascular calcification (Oros, 2012)
  • Investigate extracellular elastic matrix deposition and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering (Gacchina, 2010, 2011; Venkataraman, 2012; Phillippi, 2013)
  • Study mechanisms and effects of mechanoregulation on proliferation and function of smooth muscle cells (Jiang, 2009; Venkataraman, 2013, 2014), and develop advanced stent technology, including novel surface materials, and drug and gene delivery systems to prevent restenosis and other occlusive vasculopathies (Brito, 2010; Deshpande, 2013; Kakade, 2013; Lamichhane, 2013)

Characterization: Positive for smooth muscle cell specific alpha-actin expression.

Sejtvonal eredete

Aorta

Alkalmazás

aortic wall contraction, role of smc under normal conditions, blood pressure, distribution of oxygenated blood through systemic circulation

Elkészítési megjegyzés

  • Can be cultured at least 16 doublings

Szubkultúra rutin

Please refer to the HAOSMC Culture Protocol.

Jogi nyilatkozat

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Shay Melamed et al.
Cell reports, 42(5), 112473-112473 (2023-05-06)
Fibronectin fibrillogenesis and mechanosensing both depend on integrin-mediated force transmission to the extracellular matrix. However, force transmission is in itself dependent on fibrillogenesis, and fibronectin fibrils are found in soft embryos where high forces cannot be applied, suggesting that force
Wenhui Gao et al.
Journal of cardiothoracic surgery, 16(1), 324-324 (2021-11-08)
SCIRT has been characterized as a key player in cancer biology, while its role in other human diseases is unclear. This study explored its role in atherosclerosis, with a specific focus on its interaction with SCIRT and miR-146a. The expression
Dongsheng Lin et al.
Annals of translational medicine, 9(12), 1005-1005 (2021-07-20)
LncRNA-TCONS_00034812 is a critical player in the proliferation of aortic smooth muscle cells. It is known that artery injury plays an important role in atherosclerosis. However, the potential implication of LncRNA-TCONS_00034812 in atherosclerosis remains unclear. In this study, we collected
Yu-Lin Wang et al.
Experimental and therapeutic medicine, 21(5), 438-438 (2021-03-23)
Shear stress has been reported to result in various metabolic effects in endothelial cells (ECs), which in turn contribute to the regulation of their vascular functions. Peroxisome proliferator-activated receptors (PPARs) have been reported to regulate lipid metabolism and have been
Wenming Chen et al.
Open medicine (Warsaw, Poland), 18(1), 20230738-20230738 (2023-08-03)
UCA1 is predicted to bind to miR-132, which is a key player in the proliferation of vascular smooth muscle cells (VSMCs). This research studied the role of lncRNA UCA1 in atherosclerosis. The binding of UCA1 to miR-132 was proved by
View All Related Papers

Protocols

Culturing Human Aortic Smooth Muscle Cells

Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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