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Merck

I5627

Sigma-Aldrich

Isoprenaline hydrochloride

≥98.5% (TLC), powder, β-adrenoceptor agonist

Sinónimos:

(±)-Isoproterenol hydrochloride, 1-(3′,4′-Dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride, N-Isopropyl-DL-noradrenaline hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C11H17NO3 · HCl
Número de CAS:
Peso molecular:
247.72
Beilstein/REAXYS Number:
3917363
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Isoprenaline hydrochloride,

Quality Level

mp

165-175 °C (dec.) (lit.)

originator

Sanofi Aventis

SMILES string

Cl.CC(C)NCC(O)c1ccc(O)c(O)c1

InChI

1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H

InChI key

IROWCYIEJAOFOW-UHFFFAOYSA-N

Gene Information

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Biochem/physiol Actions

β-adrenoceptor agonist; increases cytosolic cAMP.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

For research use only

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Na Tian et al.
Diabetes, 69(7), 1355-1367 (2020-04-17)
Obesity has recently become a prevalent health threat worldwide. Although emerging evidence has suggested a strong link between the pentose phosphate pathway (PPP) and obesity, the role of transketolase (TKT), an enzyme in the nonoxidative branch of the PPP that
Aaron M Ring et al.
Nature, 502(7472), 575-579 (2013-09-24)
G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential role in human physiology, yet the molecular processes through which they bind to their endogenous agonists and activate effector proteins remain poorly understood. So far, it has not been
Michael Schwarzl et al.
Critical care medicine, 41(12), e401-e410 (2013-08-22)
We tested whether mild hypothermia impacts on circulatory and respiratory dysfunction during experimental endotoxemia. Randomized controlled prospective experimental study. Large animal facility, Medical University of Graz, Austria. Thirteen anesthetized and mechanically ventilated pigs. Lipopolysaccharide was administered for 4 hours. With
Eric M Jones et al.
eLife, 9 (2020-10-22)
The >800 human G protein-coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it challenging to understand
Jiao Li et al.
PloS one, 8(3), e58334-e58334 (2013-03-28)
Here we investigate how ß-adrenergic stimulation of the heart alters regulation of ryanodine receptors (RyRs) by intracellular Ca(2+) and Mg(2+) and the role of these changes in SR Ca(2+) release. RyRs were isolated from rat hearts, perfused in a Langendorff

Questions

1–2 of 2 Questions  
  1. What is the best way to store aliquots (water solution)? Would -20C work?

    1 answer
    1. The stability of this product in solution has not been determined. However, 10 mM stock solutions prepared in water and protected from light are expected to be stable when stored in aliquots at -20°C for at least 2 months. Avoid repeated freeze/thaw cycles. Note that solutions stored in alkaline conditions will rapidly degrade.

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  2. how to dissolve the I5627-5G(isoprenaline)?

    1 answer
    1. As mentioned on the Product Datasheet, this product is soluble in water at (50 mg/ml), yielding clear to slightly hazy, colorless to yellow or faint pink solution. The solubility in water has also been reported at 333 mg/ml. It is soluble in ethanol at 20 mg/ml.

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