The stability of this product when prepared in DMSO has not been determined. In general, solutions in DMSO should be prepared fresh and used promptly. Epinephrine is most stable in acidic aqueous solutions at pH 3.6, when stored tightly sealed under nitrogen or argon. Solutions prepared in basic buffers are unstable and turn red in color due to degradation. Published literature indicates solutions are stable for at least 1 month when stored at 4°C or 25°C. Commercial solutions are often assigned a shelf life of greater than 1 year.
E4250
(−)-Epinephrine
≥99% (HPLC), powder, adrenoceptor agonist
Sinónimos:
(−)-Adrenalin, (R)-(−)-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol, L-Adrenaline, L-Epinephrine
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About This Item
Fórmula lineal:
(HO)2C6H3CH(OH)CH2NHCH3
Número de CAS:
Peso molecular:
183.20
Beilstein/REAXYS Number:
2368277
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Nombre del producto
(−)-Epinephrine,
Quality Level
mp
215 °C (dec.) (lit.)
storage temp.
2-8°C
SMILES string
CNC[C@H](O)c1ccc(O)c(O)c1
InChI
1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
InChI key
UCTWMZQNUQWSLP-VIFPVBQESA-N
Gene Information
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)
rat ... Adra1a(29412) , Adra2a(25083) , Adrb1(24925) , Adrb2(24176) , Drd1a(24316) , Drd2(24318)
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Biochem/physiol Actions
Adrenoceptor agonist.
Features and Benefits
This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and β-Adrenoceptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Reconstitution
This product is only slightly soluble in water. Other sources state that it is soluble at 2 mg/mL in DMSO. The product solubility is tested at 50 mg/mL in 0.5 M HCl. This stock concentration can be diluted further in a buffer or medium to the required final concentration. In general, culture medium is buffered such that the final pH is not effected. The compound will remain in solution.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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When this product is reconstituted in DMSO, at what temperature should it be stored?
1 answer-
Helpful?
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Hi, Is it possible to reconstitute the epinephrine solution in something less aggressive than 0.5 M HCl ? Sincerely, Alex
1 answer-
This product is only slightly soluble in water. Other sources state that it is soluble at 2 mg/mL in DMSO. The product solubility is tested at 50mg/mL in 0.5 M HCl. This stock concentration can be diluted further in a buffer or medium to the required final concentration. In general, culture medium is buffered such that the final pH is not effected. The compound will remain in solution.
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