C4382

Carbamoylcholine chloride

≥98% (titration), crystalline

• Sinónimos: (2-Hydroxyethyl)trimethylammonium chloride carbamate, Carbachol, Carbamylcholine chloride
• Fórmula lineal: NH₂COOCH₂CH₂N(Cl)(CH₃)₃
• Número de CAS: 51-83-2
• Peso molecular: 182.65
• Beilstein: 3917459
• Número CE: 200-127-3
• Número MDL: MFCD00012011
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277829
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (titration)
• Formulario: crystalline
• color: white
• mp: 210 °C (dec.) (lit.)
• solubilidad: H₂O: 1 g/mL; ethanol: 20 mg/mL
• cadena SMILES: [Cl-].C[N+](C)(C)CCOC(N)=O
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
• Clave InChI: AIXAANGOTKPUOY-UHFFFAOYSA-N
• Información sobre el gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA2(1135) ; mouse ... Chrm1(12669) ; rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Chrna2(170945) , Chrna3(25101) , Chrna4(25590)

Descripción

Aplicación

Carbamoylcholine chloride has been used:

• to stimulate insulin secretion in transgenic mice
• to induce contraction of undifferentiated and differentiated human adipose-derived stem cells (hASCs)
• to mediate constriction of iris in pupillary light reflex studies in mice

Acciones bioquímicas o fisiológicas

Carbachol elicits tear fluid secretion by interacting with muscarinic receptors. It is an analog of acetylcholine and an antiglaucoma drug. In ciliary processes, carbachol along with nitric oxide (NO) regulates Na⁺ and K⁺-ATPase activity. It stimulates insulin vesicles transport to the secretory site to increase insulin secretion.

Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges