C1494

Carmofur

≥98% (HPLC), powder

• Sinónimos: 1-Hexylcarbamoyl-5-fluorouracil, HCFU
• Fórmula empírica (notación de Hill): C₁₁H₁₆FN₃O₃
• Número de CAS: 61422-45-5
• Peso molecular: 257.26
• Número MDL: MFCD00866284
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329774890
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to off-white
• solubilidad: DMSO: >15 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
• InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• Clave InChI: AOCCBINRVIKJHY-UHFFFAOYSA-N

Descripción

Aplicación

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Acciones bioquímicas o fisiológicas

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (M^pro) in vitro.

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur is an antineoplastic agent and a flurorouracil analog.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H361
• Consejos de prudencia: P201 - P301 + P310 + P330
• Clasificaciones de peligro: Acute Tox. 3 Oral - Repr. 2
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable