P4394

cis-Diammineplatinum(II) dichloride

≥99.99% (trace metal analysis), crystalline, macrophage activator

• Sinónimos: cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Fórmula lineal: Pt(NH₃)₂Cl₂
• Número de CAS: 15663-27-1
• Peso molecular: 300.05
• Número CE: 239-733-8
• Número MDL: MFCD00011623
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278632
• NACRES: NA.77

Propiedades

• Nombre del producto: cis-Diammineplatinum(II) dichloride, crystalline
• Formulario: crystalline
• Nivel de calidad: 200
• color: yellow
• mp: 270 °C (lit.)
• espectro de actividad antibiótica: neoplastics
• Modo de acción: DNA synthesis | interferes
• emisor: Corden
• cadena SMILES: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• Clave InChI: LXZZYRPGZAFOLE-UHFFFAOYSA-L

Descripción

Aplicación

cis-Diammineplatinum(II) dichloride has been used:

• in cell viability measurement in cochlear explants
• in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
• in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma

Acciones bioquímicas o fisiológicas

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca²⁺/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Almacenamiento y estabilidad

This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300,H315,H317,H319,H334,H335,H350
• Consejos de prudencia: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable