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T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

Sinónimos:

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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About This Item

Fórmula empírica (notación de Hill):
C10H10N2O2S
Número de CAS:
327036-89-5
Peso molecular:
222.26
Número MDL:
MFCD04973552
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329826879
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

needles

condiciones de almacenamiento

protect from light

color

white

mp

63-64.4 °C

solubilidad

DMSO: >10 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

Clave InChI

JDSJDASOXWCHPN-UHFFFAOYSA-N

Aplicación

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Acciones bioquímicas o fisiológicas

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
TDZD-8 is a selective inhibitor of GSK-3.

Características y beneficios

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000191674
0000191674
0000128588
0000123289
0000036563

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