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Key Documents

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A9563

Sigma-Aldrich

4-Aminophenylmercuric acetate

≥90% (titration)

Sinónimos:

4-(Acetoxymercurio)aniline, APMA

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About This Item

Fórmula lineal:
CH3CO2HgC6H4NH2
Número de CAS:
6283-24-5
Peso molecular:
351.75
Beilstein/REAXYS Number:
3664749
EC Number:
228-497-1
MDL number:
MFCD00007820
UNSPSC Code:
12352103
PubChem Substance ID:
57653899
NACRES:
NA.22

Quality Level

100

assay

≥90% (titration)

form

powder

mp

163-165 °C (lit.)

solubility

DMSO: soluble 10 mg/mL
H2O: soluble 5 mM
glacial acetic acid: soluble 50 mg/mL

SMILES string

CC(=O)O[Hg]c1ccc(N)cc1

InChI

1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1

InChI key

RXSUFCOOZSGWSW-UHFFFAOYSA-M

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Biochem/physiol Actions

An organomercurial activator of matrix metalloproteinases.

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
SLCK8334
SLCK8336
SLCK8335
SLCN7376
MKCL0389

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A Bianchi et al.
Osteoarthritis and cartilage, 24(11), 1961-1969 (2016-10-21)
Fibroblast Growth Factor 23 (FGF23) may represent an attractive candidate that could participate to the osteoarthritic (OA)-induced phenotype switch of chondrocytes. To address this hypothesis, we investigated the expression of FGF23, its receptors (FGFRs) and co-receptor (Klotho) in human cartilage
Jan-Olof Winberg et al.
European journal of biochemistry, 270(19), 3996-4007 (2003-09-27)
In the leukemic macrophage cell-line THP-1, a fraction of the secreted matrix metalloproteinase 9 (MMP-9) is linked to the core protein of chondroitin sulfate proteoglycans (CSPG). Unlike the monomeric and homodimeric forms of MMP-9, the addition of exogenous CaCl2 to
K R French et al.
Equine veterinary journal, 36(3), 261-266 (2004-05-19)
Acute laminitis is characterised by hoof lamellar dermal-epidermal separation at the basement membrane (BM) zone. Hoof lamellar explants cultured in vitro can also be made to separate at the basement membrane zone and investigating how this occurs may give insight
Georgina S Butler et al.
The Journal of biological chemistry, 279(15), 15615-15620 (2004-01-21)
Matrix metalloproteinases (MMPs) are an important family of extracellular proteases that process a variety of biologically significant molecules. MMPs are members of the metzincin superfamily of >770 zinc endopeptidases, which includes astacins, serralysins, adamalysins, leishmanolysins, and snapalysins. Metzincins are characterized
Reihane Ziadlou et al.
Biomolecules, 10(6) (2020-06-25)
In osteoarthritis (OA), inhibition of excessively expressed pro-inflammatory cytokines in the OA joint and increasing the anabolism for cartilage regeneration are necessary. In this ex-vivo study, we used an inflammatory model of human OA chondrocytes microtissues, consisting of treatment with
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