推荐产品
产品名称
Discovery® HS C18 高效液相色谱柱, 3 μm particle size, L × I.D. 5 cm × 2.1 mm
材料
stainless steel column
品質等級
agency
suitable for USP L1
產品線
Discovery®
特點
endcapped
製造商／商標名
Discovery®
包裝
1 ea of
標籤範圍
20% Carbon loading
參數
≤70 °C temp. range
400 bar pressure (5801 psi)
技術
HPLC: suitable
LC/MS: suitable
長度 × 內徑
5 cm × 2.1 mm
表面積
300 m2/g
表面覆盖率
3.2 μmol/m2
雜質
<10 ppm metals
基質
silica gel, high purity, spherical particle platform
fully porous particle
基質活性組
C18 (octadecyl) phase
粒徑
3 μm
孔徑
120 Å
工作pH值範圍
2-8
應用
food and beverages
分離技術
reversed phase
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一般說明
Discovery® HS C18 HPLC column (L × I.D. 5 cm × 2.1 mm) is commonly found to be stable under acidic and basic conditions.
應用
- Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotyping: This research utilizes the Discovery® HS C18 HPLC column for its superior selectivity and sensitivity in pharmacogenetic studies, providing vital data for personalized medicine approaches in drug metabolism (Abouir et al., 2024).
- A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies: This study highlights the effectiveness of the Discovery® HS C18 column in the rapid and accurate analysis of molnupiravir, emphasizing its role in supporting fast-paced pharmaceutical research and development (Reçber et al., 2022).
- Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: This application underlines the Discovery® HS C18 column′s high sensitivity and robustness in clinical diagnostics, crucial for monitoring therapeutic drugs and their metabolites in complex biological matrices (Maliszewska et al., 2020).
特點和優勢
- 稳定性好、低流失，适用于 LC-MS 分析
- 提供有适用于分析型到制备型的各种规格
- 稳定性好，以确保柱与柱和批与批之间之间优良的重现性
- 更强的疏水性能够更好地分离难分析化合物
法律資訊
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
應用
Jolanta Flieger et al.
Journal of separation science, 34(7), 733-739 (2011-03-02)
Highly hydrophilic compounds belonging to biogenic amines were analysed in the reversed-phase system, modified with the addition of ionic liquids: 1-ethyl-3-methyl-imidazolium hexafluorophosphate (EMIM PF(6)) and chaotropic salt NaPF(6) on Discovery HS C18 column at acidic conditions. The effect of the
Swati Jaiswal et al.
Journal of chromatographic science, 55(6), 617-624 (2017-03-24)
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is
Abad Khan et al.
Talanta, 84(3), 789-801 (2011-04-13)
A new, simple, economical and validated high-performance liquid chromatography linked with electrochemical detector (HPLC-ECD) method has been developed and optimized for different experimental parameters to analyze the most common monothiols and disulfide (cystine, cysteine, homocysteine, methionine, reduced (GSH) and oxidized
Bhavin N Patel et al.
Biomedical chromatography : BMC, 22(11), 1213-1224 (2008-07-25)
A simple, precise and accurate assay for the determination of 6-methoxy-2-naphthylacetic acid (6-MNA), an active metabolite of nabumetone in human plasma, was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte (6-MNA) and propranolol (internal standard, IS) were
Abad Khan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2782-2788 (2010-09-11)
A rapid, inexpensive, sensitive and specific HPLC-ECD method for the determination of lipoic acid in human plasma was developed and validated over the linearity range of 0.001-10μg/ml using naproxen sodium as an internal standard (IS). Extraction of lipoic acid and
相关内容
HPLC DiscoveryBIO HS C18 products. Available in 3µm, 5µm and 10µm particle sizes.
Chromatograms
application for HPLCapplication for HPLC我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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