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一般說明
脱铁转铁蛋白（aTF）可以补充铁或用于结合培养基中存在的游离铁，它还可用于将铁运输到哺乳动物细胞中。
應用
脱铁转铁蛋白已作为补充剂：
- 用于杜氏改良Eagle培养基/HamF12（DMEM/F-12），以培养人肾上腺皮质癌细胞
- 在DMEM/F-12中培养小鼠神经前体细胞
- 收集NCSU23培养基培养猪卵巢腔前卵泡
生化／生理作用
脱铁转铁蛋白（aTF）是一种内源性铁螯合剂，通过清除游离铁和防止有毒活性氧（ROS）的形成对宿主起到保护作用。它对地中海贫血有治疗作用。铁释放后，受体结合的脱铁转铁蛋白到达细胞表面，而不是被运输到溶酶体降解。细胞表面具有中性的pH值，促进脱铁转铁蛋白从受体释放，在此处再次循环并结合额外的铁，以进一步将铁传递到细胞。
其他說明
非血红素铁转运蛋白。
免責聲明
供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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商品
转铁蛋白和其他细胞培养成分如何影响无血清、无蛋白细胞培养系统（用于生物制造包括单克隆抗体在内的异源蛋白）的性能。本页介绍转铁蛋白的体外化学和生物化学。
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