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生物源
mouse
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
26.2 kDa
包裝
pkg of 10 μg
技術
cell culture | embryo: suitable
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... INHBA(3624)
一般說明
Activin A is a member of the TGF (transforming growth factor)-β family of proteins produced by many cell types throughout development. Mouse Activin A has 100% amino acid sequence identity to human, rat, porcine, bovine and feline proteins. Recombinant mouse Activin A is a nonglycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa.
應用
Activin A has been used:
- to induce differentiation of embryonic stem cells to pancreatic β cells
- in the induction of bone marrow-derived mesenchymal stem cells to insulin-producing cells
- to induce endoderm differentiation from human embryonic stem cells
- as a component of β cell induction medium.
生化／生理作用
Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two β A chains and is not biologically active until the N terminal propeptide is cleaved from each chain. Activin A is involved in mesoderm formation and hematopoietic development.
外觀
Recombinant mouse Activin A is lyophilized with 0.02% TFA.
準備報告
Centrifuge the vial prior to opening.
重構
Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
其他說明
MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro.
Sun Y
Chinese Medical Journal (English Edition), 120, 771-776 (2007)
Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.
Gray AM
Science, 247, 1328-1330 (1990)
In vitro derivation of functional insulin-producing cells from human embryonic stem cells.
Jiang W
Cell Research, 17, 333-344 (2007)
Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid.
Shi Y
Stem Cells, 23, 656-662 (2005)
Functional analysis of activins during mammalian development.
Matzuk MM
Nature, 374, 354-356 (1995)
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