推荐产品
生物源
human
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
~20 kDa
包裝
pkg of 50 μg
技術
activity assay: suitable
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... LCN2(3934)
一般說明
基因 LCN2(脂质运载蛋白 2)定位于人类染色体 9q34。LCN2 是一种分泌型糖蛋白,是一种脂肪因子。它由许多细胞表达,如呼吸和肠上皮细胞、内皮细胞、肾小管细胞和心肌细胞等。LCN2 属于脂质运载蛋白家族。由大肠杆菌表达由178个氨基酸组成的重组人Lipocalin-2(a.a. 21-198,登录号NP_00555),并使用专有技术纯化。
應用
人LCN2(脂质运载蛋白 2)已被用于细胞增殖试验。
生化/生理作用
LCN2(脂质运载蛋白 2)可能与肥胖及其相关脂肪炎症相关。 LCN2 还参与包括细胞分化、肿瘤发生和细胞凋亡在内的多种过程。它是一种急性肾损伤的早期标志物。LCN2 在心力衰竭患者中上调。可与 MMP9(基质金属蛋白酶-9)结合并控制其稳定。 LCN2 的表达变化与许多癌症相关,包括乳腺癌、结直肠癌、胰腺癌、卵巢癌、胃癌、甲状腺癌、卵巢癌、膀胱癌和肾癌。
外觀
不含添加剂的冻干品。
重構
打开样品瓶之前需离心。避免反复冻融。
用水复溶至浓度 0.1-1 mg/mL。然后将溶液进一步稀释至其他水溶液。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(8), 565-571 (2015-12-17)
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Scientific Reports, 4, doi: 10-doi: 10 (2014)
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Journal of Molecular Medicine, 87, 803-813 (2009)
Plasma levels of neutrophil gelatinase-associated lipocalin in children with heart failure.
Therapeutic Advances in Cardiovascular Disease, 10, 30-36 (2016)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门