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生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
lyophilized
分子量
~30 kDa
包装
pkg of 25 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... ADIPOQ(9370)
一般描述
脂联素（也称为 Acrp30，AdipoQ）是一种脂肪细胞特异性分泌蛋白，在血浆中循环。在脂肪细胞分化过程中被诱导，其分泌受到胰岛素的刺激。 该蛋白具有羧基末端球状结构域和氨基末端胶原结构域。该基因定位于人类染色体 3q27人脂联素与小鼠的氨基酸同源性为 83%，与大鼠的同源性为 90%。
应用
脂联素 (Adiponectin) 已被用于研究脂联素对雄烯二酮分泌和氧化应激的影响。
生化/生理作用
脂联素（也称为 Acrp30，AdipoQ）具有抗动脉粥样硬化和抗炎特性。在能量稳态、肥胖等多种生理过程中发挥作用。肥胖者血浆脂联素水平降低，水平降低与胰岛素抵抗和高胰岛素血症有关。通过与脂联素受体、AdipoR1 和 AdipoR2 相互作用表现出抗糖尿病操作。低水平的脂联素也与高血压和血脂异常有关。276G 位点的基因突变与子宫内膜癌的发病风险有关。
外形
从 25 mM Tris、0.15 mNaCl（pH 7.4，含 50 μg 牛血清白蛋白 (BSA)/1μg 脂联素）过滤的 0.2 μm 溶液冻干。
重悬
在含有至少 0.1%BSA 的 PBS 中重新制备浓度为 0.1-1.0 mg/mL 的溶液。然后将此贮备液稀释于其他水性缓冲液中，4℃ 保存 1 周或 –20℃ 保存备用。
打开样品瓶之前需离心。避免反复冻融。
分析说明
人重组脂联素抑制小鼠髓系细胞 M1 增殖的能力决定其活性。效果的 ED50 一般为 1-7μg/ml。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Eric R Hugo et al.
Environmental health perspectives, 116(12), 1642-1647 (2008-12-17)
The incidence of obesity has risen dramatically over the last few decades. This epidemic may be affected by exposure to xenobiotic chemicals. Bisphenol A (BPA), an endocrine disruptor, is detectable at nanomolar levels in human serum worldwide. Adiponectin is an
Thorhallur I Halldorsson et al.
Environmental health perspectives, 120(5), 668-673 (2012-02-07)
Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Hotta K
Arteriosclerosis, Thrombosis, and Vascular Biology, 20, 1595-1599 (2000)
Donal O'Shea et al.
PloS one, 5(1), e8660-e8660 (2010-01-29)
Obese individuals who smoke have a 14 year reduction in life expectancy. Both obesity and smoking are independently associated with increased risk of malignancy. Natural killer cells (NK) are critical mediators of anti-tumour immunity and are compromised in obese patients
Jong-Rung Tsai et al.
PloS one, 10(12), e0144462-e0144462 (2015-12-15)
Adipose tissue is now considered as an endocrine organ involved in metabolic and inflammatory reactions. Adiponectin, a 244-amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. Curcumin (diferuloylmethane) is the principal curcuminoid of the popular Indian spice, turmeric.
商品
脂肪组织中的胰岛素耐受性减少了循环游离脂肪酸的摄入，并增加了脂肪酶对储存甘油三酯的水解。了解与胰岛素耐受性相关的激素、细胞因子和脂肪因子。
Lipid Induced Insulin Resistance
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