推荐产品
生物源
rat
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
效力
≤5.0 ng/mL ED50
分子量
36.2 kDa
包裝
pkg of 10 μg
雜質
tested
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
rat ... CSF1(78965)
一般說明
Macrophage colony stimulating factor (M-CSF) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The gene encoding this protein is localized on rat chromosome 2q34. The human protein is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant rat M-CSF is a 36.2kDa homodimeric protein containing two 155 amino acid polypeptide subunits.
生化／生理作用
Macrophage colony stimulating factor (M-CSF) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation.
外觀
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Chemokines and the tissue-specific migration of lymphocytes.
Kunkel, E.J. and Butcher E.C.
Immunity, 1, 1-4 (2002)
Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts.
Paulus P
Cancer Research, 66(8), 4349-4356 (2006)
Stanley, E.R.
The Cytokine Handbook, 387-418 (1994)
Yuying Tang et al.
Brain, behavior, and immunity, 68, 248-260 (2017-10-31)
Accumulation of microglia occurs in the dorsal horn in the rodent model of chronic post ischemic pain (CPIP), while the mechanism how microglia affects the development of persistent pain largely remains unknown. Here, using a rodent model of CPIP induced
The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification.
Van Wesenbeeck L
Proceedings of the National Academy of Sciences of the USA, 99(22), 14303-14308 (2002)
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