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生物来源
mouse
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
效能
≤10 ng/mL ED50
分子量
36.4 kDa
包装
pkg of 10 μg
技术
cell culture | mammalian: suitable
杂质
<0.1 EU/μg endotoxin, tested
颜色
white to off-white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... CSF1(12977)
相关类别
一般描述
M-CSF（巨噬细胞集落刺激因子）是由淋巴细胞、单核细胞、成纤维细胞、内皮细胞、成肌细胞和成骨细胞等多种细胞产生的有效造血因子。该蛋白通过受体CSF1R（集落刺激因子1受体）起作用。人类的在鼠系统中有活性，但鼠的对人体细胞没有活性。重组鼠M-CSF是36.4kDa的同源二聚体蛋白，含有两个长度为156个氨基酸的多肽亚基。
生化/生理作用
M-CSF是由淋巴细胞、单核细胞、成纤维细胞、内皮细胞、成肌细胞和成骨细胞等多种细胞产生的有效造血因子。重组鼠M-CSF是36.4 kDa的同源二聚体蛋白，含有两个长度为156个氨基酸的多肽亚基。
M-CSF（巨噬细胞集落刺激因子）是血单核细胞、组织巨噬细胞及其祖细胞的细胞增殖、分化和存活的关键调节因子。M-CSF在调节真皮厚度、男女生育能力方面发挥着重要作用。临床上用于治疗感染、恶性肿瘤和动脉粥样硬化。可促进骨髓移植后造血功能的恢复。M-CSF也是多效生长因子，在生殖和器官发生中起着至关重要的作用。缺乏可导致生长迟缓、神经问题和生殖问题以及乳腺、骨和胰腺的发育缺陷。
序列
MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP
外形
10 mM磷酸钠，50 mM氯化钠，pH 7.5。
重悬
打开样品瓶之前需离心。 用水配制成浓度为0.1-0.5 mg/ml的溶液。 不可涡旋。 该溶液可在2-8°C下储存长达1周。 对于长期储存，建议用含有稳定剂（例如5％海藻糖）的缓冲液进一步稀释，并按使用量分装储存于-20°C至-80°C。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
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