SRP3124

Neurturin human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

• 别名: NRTN, NTN
• UNSPSC代码: 12352202
• NACRES: NA.75

属性

• 生物来源: human
• 重组: expressed in E. coli
• 方案: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 表单: lyophilized
• 分子量: 11.8 kDa
• 包装: pkg of 20 μg
• 技术: cell culture | mammalian: suitable
• 杂质: <0.1 EU/μg endotoxin, tested
• 颜色: white to off-white
• UniProt登记号: Q99748
• 运输: wet ice
• 储存温度: −20°C
• 基因信息: human ... NRTN(4902)

说明

一般描述

Neurturin (NTN) is a disulfide-linked homodimer neurotrophic factor structurally related to glial cell derived neurotrophic factor (GDNF), artemin, and persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8kDa polypeptide monomers (206 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

生化/生理作用

Neurturin (NTN) signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. NTN modulates spermatogenesis, kidney morphogenesis and controls smooth muscle of penile blood vessels and several intrapelvic organs.

序列

MARLGARPCG LRELEVRVSE LGLGYASDET VLFRYCAGAC EAAARVYDLG LRRLRQRRRL RRERVRAQPC CRPTAYEDEV SFLDAHSRYH TVHELSAREC ACV

外形

Lyophilized from 10 mM Sodium Citrate, pH 4.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable