SML4022
Didemnin B
≥95% (HPLC)
别名:
(2S)-2-Hydroxypropanoyl-L-prolyl-N-methyl-D-leucyl-L-threonyl-(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl-L-leucyl-L-prolyl-N,O-dimethyl-L-tyrosine (9→4)-lactone, N-[1-[(2S)-2-Hydroxy-1-oxopropyl]-L-prolyl]didemnin A, NSC 325319, NSC 333841
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所有图片(1)
About This Item
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品質等級
化驗
≥95% (HPLC)
形狀
(Powder or Lyophilized powder or film)
顏色
white to off-white
儲存溫度
-10 to -25°C
SMILES 字串
O=C1N2[C@]([H])(C(N(C)[C@@H](CC3=CC=C(OC)C=C3)C(O[C@H](C)[C@H](NC([C@H](N(C([C@H]4N(C([C@H](C)O)=O)CCC4)=O)C)CC(C)C)=O)C(N[C@]([H])([C@H](CC)C)[C@@H](O)CC(O[C@@H](C(C)C)C([C@H](C)C(N[C@H]1CC(C)C)=O)=O)=O)=O)=O)=O)CCC2
生化／生理作用
Marine-derived cyclic depsipeptide with potent antiviral, immunosuppressive and anticancer activities; induces rapid apoptosis; elongation factor 1A inhibitor.Didemnin B is a marine-derived cyclic depsipeptide with potent antiviral, immunosuppressive and anticancer activities. Didemnin B selectively induces rapid apoptosis through dual inhibition of palmitoyl-protein thioesterase 1 (PPT1) and eukaryotic translation elongation factor 1 alpha 1 (EEF1A1). Binds to the eEF1A(GTP)-aa-tRNA ternary complex and inhibits translation. Didemnin B improves nonalcoholic fatty liver disease (NAFLD) histopathology, glucose homeostasis, and dyslipidemia in western diet-induced obese mice.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Malia B Potts et al.
Nature chemical biology, 11(6), 401-408 (2015-04-14)
Modern cancer treatment employs many effective chemotherapeutic agents originally discovered from natural sources. The cyclic depsipeptide didemnin B has demonstrated impressive anticancer activity in preclinical models. Clinical use has been approved but is limited by sparse patient responses combined with
Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice
Physiological Reports, 4(17) (2016)
Manuel F Juette et al.
eLife, 11 (2022-10-21)
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eEF1A), which escorts aa-tRNA as an eEF1A(GTP)-aa-tRNA ternary
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