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Fuqiang Chen et al.
Nature methods, 8(9), 753-755 (2011-07-19)
Zinc-finger nucleases (ZFNs) have enabled highly efficient gene targeting in multiple cell types and organisms. Here we describe methods for using simple ssDNA oligonucleotides in tandem with ZFNs to efficiently produce human cell lines with three distinct genetic outcomes: (i)
T N Wiegner et al.
Marine pollution bulletin, 114(2), 952-961 (2016-11-22)
Spatial and temporal patterns of coastal microbial pollution are not well documented. Our study examined these patterns through measurements of fecal indicator bacteria (FIB), nutrients, and physiochemical parameters in Hilo Bay, Hawai'i, during high and low river flow. >40% of
Leonel Armas-López et al.
Oncotarget, 8(40), 67056-67081 (2017-10-06)
Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be
Eun Jung Thak et al.
Journal of microbiology (Seoul, Korea), 56(1), 11-23 (2018-01-05)
Protein glycosylation, the most universal and diverse post-translational modification, can affect protein secretion, stability, and immunogenicity. The structures of glycans attached to proteins are quite diverse among different organisms and even within yeast species. In yeast, protein glycosylation plays key
Hyong Woo Choi et al.
PloS one, 10(11), e0143447-e0143447 (2015-11-26)
The plant hormone salicylic acid (SA) controls several physiological processes and is a key regulator of multiple levels of plant immunity. To decipher the mechanisms through which SA's multiple physiological effects are mediated, particularly in immunity, two high-throughput screens were
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