SML3711

DENSPM tetrahydrochloride

≥98% (HPLC)

• 别名: BE 333 HCl, BENSpm HCl, DENSpm 4HCl, N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-bis(ethyl)norspermine tetrahydrochloride
• 经验公式（希尔记法）: C₁₃H₃₂N₄· 4HCl
• CAS号: 156886-85-0
• 分子量: 390.26
• MDL编号: MFCD00871200
• UNSPSC代码: 41121800
• UNSPSC代码: 12352200
• NACRES: NA.21

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: desiccated
• 颜色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear
• 储存温度: -10 to -25°C

说明

生化/生理作用

DENSPM HCl is a nontoxic polyamine analog that enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model.

Polyamine pathway inhibitor; potent inducer of spermidine/spermine N1-acetyltransferase

注意

Hygroscopic

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable