SML2780

ML402

≥98% (HPLC)

• 别名: N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide, N-[2-(4-Chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide
• 经验公式（希尔记法）: C₁₄H₁₄ClNO₂S
• CAS号: 298684-44-3
• 分子量: 295.78
• MDL编号: MFCD01990273
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: −20°C
• SMILES字符串: ClC1=CC=C(OCCNC(C2=CC=CS2)=O)C(C)=C1
• InChI: 1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
• InChI key: RULQUKFOBAPKKR-UHFFFAOYSA-N

说明

生化/生理作用

Activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels

ML402 is a selective activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) potassium channels. It was used to determine a cryptic selectivity filter binding site of the K2P2.1 (TREK-1) channel, designated the K2P modulator pocket. This binding pocket stabilizes an active "leak-mode" conformation, binding small-molecule activators that restrict the mobility of the selectivity filter and surrounding structure.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable