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Merck
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文件

SML1833

Sigma-Aldrich

ML385

≥98% (HPLC), powder, Nrf2 transcription factor inhibitor

别名:

N- [4- [2,3-二氢-1-（2-甲基苯甲酰基）-1H-吲哚-5-基] -5-甲基-2-噻唑基] -1,3-苯并二氧杂环戊-5-基 -乙酰胺

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About This Item

经验公式（希尔记法）:
C29H25N3O4S
CAS号:
846557-71-9
分子量:
511.59
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

ML385, ≥98% (HPLC)

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 10 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5

生化／生理作用

ML385 通过与 Neh1 结合来抑制 Nrf2 转录因子的活性，Neh1 是一个 CNC-bZIP 结构域，其能够使 Nrf2 与小 Maf 蛋白异二聚化，从而阻断 NRF2 转录活性。人们已对激活 Nrf2 进行了大量研究，因为它诱导细胞保护抗氧化基因的表达。然而，一些癌细胞可能以类似的方式利用 Nrf2 来使其存活。Nrf2 在某些癌症（例如非小细胞肺癌（NSCLC））中过表达，这通常是由于 KEAP1 功能缺失突变引起的，KEAP1 靶向 Nrf2 导致其发生蛋白酶体降解。研究发现 ML385 对带有 KEAP1 突变的 NSCLC 细胞具有特异性和选择性的抗肿瘤活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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