推荐产品
产品名称
辛-(R)-2HG, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
film
储存条件
desiccated
颜色
colorless
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O[C@H](CCC(=O)O)C(=O)OCCCCCCCC
InChI key
UJZOKTKSGUOCCM-LLVKDONJSA-N
应用
辛基-（R）-2羟基戊二酸酯（HG）已被用作胶质母细胞瘤细胞中的膜渗透性致癌代谢物（oncometabolite），用于测试其对NANOG转录因子表达的影响。它还被用作酮戊二酸酯（α-KG）依赖性脱氧酶α的竞争性抑制剂。
生化/生理作用
抑制 α-酮戊二酸/α-KG 依赖性双加氧酶类的肿瘤代谢产物 D-2-羟基戊二酸的膜渗透前体形式。
辛基-(R)-2HG (Octyl-D-2HG) 是肿瘤细胞因 NADP + 依赖性异柠檬酸脱氢酶基因 IDH1 和 IDH2 突变而产生的肿瘤代谢产物 D-2-羟基戊二酸盐 (D-2HG) 的膜渗透前体形式。D-2HG 通过与 α-KG 结合竞争抑制多种 α-酮戊二酸/α-KG-依赖性双加氧酶。通过 Octyl-(R)-2HG 处理 (1-50 mM) 的细胞 D-2HG 传递显示出抑制脱甲基酶活性（~148%H3K9me2 和 ~310%H3K79me2 上调；U-87 mg 中 50 mm）以及因为分别抑制 α-KG-依赖性双加氧酶脯氨酰羟化酶 (PHD) 和胶原脯氨酰-4-羟化酶 (C-P4H)而增加 HIF-1α通过, 降低内皮抑素水平。
制备说明
该化合物未报告密度。分子量为260.33。DMSO中的溶解性经测试为2 mg/mL，然而其他数据来源表明其在DMSO中的溶解度可高达10 mg/mL。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
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Makoto Hirata et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2829-2834 (2015-03-03)
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By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found
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