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Merck
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文件

H8378

Sigma-Aldrich

2-羟基-D-谷氨酸 二钠盐

≥95% (GC), cell analysisfor peptide synthesis

别名:

（R）-2-羟基戊二酸, （R）-2-羟基戊二酸二钠

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About This Item

线性分子式:
C5H6O5Na2
CAS号:
103404-90-6
分子量:
192.08
Beilstein:
5318041
MDL號碼:
MFCD00069573
分類程式碼代碼:
12352106
PubChem物質ID:
57654274
NACRES:
NA.22

product name

2-羟基-D-谷氨酸 二钠盐, ≥95% (GC)

化驗

≥95% (GC)

形狀

powder

顏色

white to off-white

應用

cell analysis
peptide synthesis

儲存溫度

−20°C

SMILES 字串

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

InChI 密鑰

DZHFTEDSQFPDPP-HWYNEVGZSA-L

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相关类别

應用

Dα-羟基戊二酸二钠盐可以用作肽合成中的试剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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M Hans et al.
European journal of biochemistry, 265(1), 404-414 (1999-09-22)
Component D (HgdAB) of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum was purified to homogeneity. It is able to use component A from Acidaminococcus fermentans (HgdC) to initiate catalysis together with ATP, Mg2+ and a strong reducing agent such as Ti(III)citrate. Component
Shan Jin et al.
Nature communications, 14(1), 6638-6638 (2023-10-21)
Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.
Liu Y, Gilbert MR, Kyprianou N, et al.
Acta Neuropathologica, 128(5), 723-732 (2014)
Ying Zhang et al.
Cancer research, 79(19), 4994-5007 (2019-08-09)
Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and
Postoperative risk of IDH mutant glioma-associated seizures and their potential management with IDH mutant inhibitors.
Drumm, et al.
The Journal of Clinical Investigation (2023)
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实验方案

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Chromatograms

application for HPLCapplication for HPLC

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