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化驗
≥98% (HPLC)
形狀
powder
儲存條件
protect from light
顏色
red
溶解度
DMSO: >20 mg/mL
儲存溫度
2-8°C
SMILES 字串
CC1=C(SSC1=S)c2cnccn2
InChI
1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
InChI 密鑰
CKNAQFVBEHDJQV-UHFFFAOYSA-N
一般說明
Oltipraz是一种二硫醇衍生物，是二硫代硫酮类有机硫化合物的成员。它具有抗肿瘤，抗氧化，抗炎和放射防护的特性。 可以抵抗多种致癌物。Oltipraz可以用作抗血吸虫药。
生化／生理作用
Oltipraz是Nrf2的激活剂。 Nrf2（NF-E2相关因子2）是一种转录因子，可与抗氧化反应元件(ARE) 结合并激活这些基因。 Oltipraz可激活Nrf2，随后提高编码抗氧化剂和多药耐药相关蛋白的解毒基因的表达，以介导其化学预防功效。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia
Lam S, et al.
Journal of the National Cancer Institute, 94(13), 1001-1009 (2002)
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
Iida K, et al.
Cancer Research, 64(18), 6424-6431 (2004)
Alberto Izzotti et al.
Cancer prevention research (Philadelphia, Pa.), 3(1), 62-72 (2010-01-07)
We previously showed that exposure to environmental cigarette smoke (ECS) for 28 days causes extensive downregulation of microRNA expression in the lungs of rats, resulting in the overexpression of multiple genes and proteins. In the present study, we evaluated by
Sang Geon Kim et al.
The Journal of pharmacy and pharmacology, 63(5), 627-635 (2011-04-16)
Oltipraz, a cancer chemopreventive agent, has an anticirrhotic effect in animals. A phase II trial was designed to investigate the preliminary efficacy of oltipraz therapy in liver fibrosis or cirrhosis. Of 83 patients who were randomized to receive placebo, oltipraz
Yoko Yagishita et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-14)
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the regulation of inflammation and cellular detoxication pathways. The contribution of the NRF2
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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