SML1570

Arglabin

≥98% (HPLC)

• 别名: (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one, 1(R),10(S)-Epoxy-5(S),5(S),7(S)-guaia-3(4),11(13)-dien-6,12-olide
• 经验公式（希尔记法）: C₁₅H₁₈O₃
• CAS号: 84692-91-1
• 分子量: 246.30
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 生物来源: semisynthetic (from parthenolide)
• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: protect from light
• 颜色: white to beige
• 储存温度: −20°C
• SMILES字符串: O1[C@@]32[C@@]1(CC[C@@H]4[C@H](OC(=O)C4=C)[C@@H]3C(=CC2)C)C
• InChI: 1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11-,12-,14-,15+/m0/s1
• InChI key: UVJYAKBJSGRTHA-ZCRGAIPPSA-N

说明

生化/生理作用

Arglabin is a natural product with antitumor and anti-inflammatory activity. Arglabin competitively inhibits the binding of farnesyl diphosphate to farnesyl transferase (FTase), preventing the activation of RAS proto-oncogene by preventing the incorporation of farnesyl pyrophosphate into human H-ras proteins. Arglabin is also an inhibitor of the NLRP3 inflammasome. Arglabin reduces inflammation and plasma lipids and has shown a marked reduction in atherosclerotic lesions.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302,H315,H319,H335
• 预防措施声明: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危险分类: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 靶器官: Respiratory system
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable