推荐产品
product name
利普司他丁-1, >98% (HPLC)
品質等級
化驗
>98% (HPLC)
形狀
powder
顏色
white to light brown
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
InChI
1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChI 密鑰
YAFQFNOUYXZVPZ-UHFFFAOYSA-N
應用
Liproxstatin-1 在细胞活力试验和脂质过氧化测定中用作细胞死亡抑制剂。
生化／生理作用
Liproxstatin-1 是铁死亡的强效抑制剂，铁死亡是一种非凋亡形式的细胞死亡，以铁依赖性致死脂质活性氧簇 (ROS) 蓄积为特征。Liproxstatin-1 在人类细胞和缺血/再灌注诱导的小鼠组织损伤模型中抑制了铁死亡。谷胱甘肽过氧化物酶 4 (Gpx4) 的基因敲除已被证明可引起细胞死亡的铁死亡。Liproxstatin-1 能够抑制 Gpx4 基因敲除小鼠的铁死亡。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.
Ingold I, et al.
Cell, 172(3), 409-422 (2018)
Yilong Zou et al.
Nature, 585(7826), 603-608 (2020-09-18)
Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions2-5. However
Wen-Hsuan Yang et al.
Molecular cancer research : MCR, 18(1), 79-90 (2019-10-24)
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To investigate metabolic susceptibility, we performed nutrigenetic screens on a panel of clear cell and serous ovarian cancer cells and identified cystine
Alejandra M Martinez et al.
FEBS open bio, 9(4), 582-593 (2019-04-16)
Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Deletion of the Gpx4 gene in mice revealed that neurons are sensitive to ferroptosis in vivo. However
Masahiro Yoshida et al.
Nature communications, 10(1), 3145-3145 (2019-07-19)
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis resulting in excessive oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease
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