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产品名称
雷西莫特, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
protect from light
颜色
white to tan
溶解性
DMSO: 10 mg/mL, clear (warmed to 60 °C)
运输
wet ice
储存温度
−20°C
SMILES字符串
CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
InChI
1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
InChI key
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
应用
瑞喹莫德已用于刺激骨髓源性树突状细胞(BMDC)(和B细胞。它也被用作恶性黑色素瘤细胞系B16F10中Toll样受体(TLR7)的配体。
雷西莫特可用于免疫学和癌症相关的细胞信号传导研究。
生化/生理作用
瑞喹莫德是314.4 Da分子，可在 L. infantum Sp内脏感染期间引发免疫功能。它可以介导粒细胞、巨噬细胞、白细胞和树突状细胞的运输。它是治疗皮肤肿瘤的建议外敷药物，例如光化性角化病(AK)和表浅性基底细胞癌。
雷西莫特(R-848)是一种有效的TLR7/TLR8合成激动剂，具有抗病毒和抗肿瘤活性。
雷西莫特属于咪唑喹啉胺类化合物，具有免疫调节作用。雷西莫特可提高细胞因子的水平，如TNF-α、IL-6和IFN-α。
雷西莫特是toll样受体7和8（TLR-7和TLR-8）的激动剂。
特点和优势
《受体分类和信号转导》手册的 细胞因子受体（白细胞介素-1受体/TIR家族） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Anette Christ et al.
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Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate
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Szili,D, et al.
MAbs, 6(4), 991-999 (2014)
D H Dockrell et al.
The Journal of antimicrobial chemotherapy, 48(6), 751-755 (2001-12-06)
Augmenting the host's natural immune response to viruses by the administration of exogenous cytokines such as interferon-alpha (IFN-alpha) is a strategy increasingly employed in antiviral therapeutics. Enhancing the release of endogenous cytokines is, however, an alternative approach. The imidazoquinolinamines imiquimod
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Losier TT, et al.
Cell Reports, 26(8), 2150-2165 (2019)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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