推荐产品
生物源
Toxoplasma gondii
重組細胞
expressed in E. coli
化驗
>95% (SDS-PAGE)
形狀
lyophilized
分子量
~20 kDa by SDS-PAGE
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
<0.01 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
Toxoplasma gondii ... PRF(7900190)
生化／生理作用
Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.
外觀
Lyophilized from PBS.
重構
Reconstitute with 100 μL deionized water.
其他說明
Recombinant profilin (Toxoplasma gondii) (aa 1-163).
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
UNC93B1 is essential for TLR11 activation and IL-12 dependent host resistance to Toxoplasma Gondii.
Pifer R, et al.
The Journal of Biological Chemistry, M110-M110 (2010)
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Koblansky A A, et al.
Immunity, 38(1), 119-130 (2013)
Erik W Martin et al.
Science signaling, 13(620) (2020-02-27)
The complex signaling dynamics of transcription factors can encode both qualitative and quantitative information about the extracellular environment, which increases the information transfer capacity and potentially supports accurate cellular decision-making. An important question is how these signaling dynamics patterns are
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门