推荐产品
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~33.4 kDa
种属反应性
human
技术
indirect immunofluorescence: suitable
western blot: 1 μg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PYCR1(5831)
一般描述
Pyrroline-5-carboxylate reductase 1 (PYCR1) is a housekeeping gene.The gene is located on human chromosome 17q25.3.
免疫原
PYCR1 (NP_008838.2, 1 a.a. ~ 319 a.a) full-length human protein.
Sequence
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
Sequence
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
生化/生理作用
Pyrroline-5-carboxylate reductase 1 (PYCR1) acts as a prognostic biomarker for breast cancer.Mutations in this gene affects mitochondrial function and is associated with connective tissue disorder cutis laxa.It helps in cell metabolism.This protein catalyses the conversion of 1-piperideine-6-carboxylate (P6C) into pipecolic acid.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers
Ding, Ji , et al.
Carcinogenesis, 38(5), 519-531 (2017)
Human pyrroline-5-carboxylate reductase (PYCR1) acts on Delta 1-piperideine-6-carboxylate generating L-pipecolic acid
Struys,, et al.
Journal of inherited metabolic disease, 37(3), 327-332 (2014)
Improving the prediction accuracy in classification using the combined data sets by ranks of gene expressions
Kim, Ki, et al.
BMC Bioinformatics, 9(1), 283-283 (2008)
Resolving the cofactor binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1
Christen, et al.
Test, jbc-M117 (2017)
Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer
Zeng, Te, et al.
Medical Oncology (Northwood, London, England), 34(2), 27-27 (2017)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持