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MAB2617

Sigma-Aldrich

抗Kindlin-2抗体,克隆3A3

clone 3A3, from mouse

别名:

Mitogen-inducible gene 2 protein, Pleckstrin homology domain-containing family C member 1, fermitin family homolog 2, kindlin 2, mitogen inducible gene 2 protein

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

3A3, monoclonal

物種活性

human

物種活性(以同源性預測)

bovine (based on 100% sequence homology), rat (98% sequence homology), mouse (98% sequence homology)

技術

immunocytochemistry: suitable
western blot: suitable

同型

IgG1κ

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... FERMT2(10979)

一般說明

Kindlin家族是一组黏着斑蛋白,由于它们具有结合和激活整联蛋白的能力而成为人们关注的焦点。这种能力的异常已将Kindlin与几种遗传和获得性疾病联系起来,例如Kindler综合征,癌症和白细胞粘附缺乏症。亚型Kindlin-2专门参与将migfilin蛋白募集到局部粘连位点以进行细胞ECM各种相互作用,协调肌动蛋白的生产和细胞形状的修饰。它还积极参与连接ECM粘连位点和肌动蛋白细胞骨架(Shi,2007)。Kindlin-2在整个组织中普遍表达。

特異性

该抗体识别Kindlin-2。

免疫原

GST 标记的重组蛋白对应于人Kindlin-2。
表位:未知

應用

研究子类别
细胞骨架
研究类别
细胞结构
该抗Kindlin-2抗体克隆3A3经过验证可用在 WB,IC 中检测Kindlin-2。

品質

通过蛋白质印迹在HeLa 细胞裂解物中进行了评估。

蛋白质印迹分析:0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。

標靶描述

~70 kDa

外觀

在含0.1 M Tris-甘氨酸(pH 7.4,150 mM NaCl)和0.05%叠氮化钠的缓冲液中的纯化的小鼠单克隆IgG1κ。
形式:纯化
纯化的蛋白G

儲存和穩定性

自收到之日起,在 2-8°C 条件下可稳定保存1年

分析報告

对照
HeLa细胞裂解物

其他說明

浓度:请参考批次特异性浓缩物的分析证书。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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访问文档库

Huanqing Gao et al.
JCI insight, 4(13) (2019-07-12)
Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of mesenchymal stem cell differentiation and skeletal development. In this study, we generated adipose tissue-specific conditional knockout of
Lihua Qi et al.
Cell death & disease, 10(12), 890-890 (2019-11-27)
Kindlin-2 plays an important role in the regulation of cardiac structure and function. Depletion of Kindlin-2 contributes to cardiac hypertrophy and progressive heart failure, however, the precise mechanisms involved in this process remain unclear. GATA4 is a critical transcription factor
Jie Lin et al.
Journal of experimental & clinical cancer research : CR, 36(1), 134-134 (2017-10-04)
Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. Immunohistochemistry was used to investigate Kindlin-2 expression in
Lihua Qi et al.
FEBS letters, 589(16), 2155-2162 (2015-07-06)
Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with α-actinin-2 at the Z-disc of mouse cardiac
Khalid Sossey-Alaoui et al.
Cancer research, 77(18), 5129-5141 (2017-07-09)
Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2

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