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Merck
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文件

S2812

Sigma-Aldrich

SNC80

≥98% (HPLC), solid

别名:

(+)-4-[(αR)-α-((2S,5R)-4-烯丙基-2,5-二甲基-1-哌嗪基)-3-甲氧基苄基]-N,N-二乙基苯甲酰胺, SNC 80, SNC-80

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About This Item

经验公式（希尔记法）:
C28H39N3O2
CAS号:
156727-74-1
分子量:
449.63
MDL號碼:
MFCD00672673
分類程式碼代碼:
12352200
PubChem物質ID:
24278698
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: soluble

SMILES 字串

CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1

InChI 密鑰

KQWVAUSXZDRQPZ-QNWUEUMSSA-N

基因資訊

human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613) , Oprm1(25601)

應用

给予大鼠SNC80以研究一氧化氮合酶在外周抗伤害感受机制中的作用。5

生化／生理作用

SNC80是δ阿片受体的高度选择性激动剂，但也与μ-δ阿片受体异聚体结合以在小鼠中产生镇痛作用。2它还充当抗抑郁药3，引起多巴胺相关行为并增强对精神刺激药的行为反应。4
SNC80是δ-阿片受体激动剂。

特點和優勢

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Behavioural brain research, 278, 429-434 (2014-12-03)
The delta opioid receptor (DOR) has raised much interest for the development of new therapeutic drugs, particularly to treat patients suffering from mood disorders and chronic pain. Unfortunately, the prototypal DOR agonist SNC80 induces mild epileptic seizures in rodents. Although
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The Journal of pharmacology and experimental therapeutics, 344(1), 179-188 (2012-10-26)
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Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this
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