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Merck
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文件

N115

Sigma-Aldrich

Naltrindole hydrochloride

≥97.5% (HPLC), solid, δ-opioid receptor antagonist

别名:

NTI hydrochloride

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About This Item

经验公式（希尔记法）:
C26H26N2O3 · HCl
CAS号:
111469-81-9
分子量:
450.96
MDL號碼:
MFCD00069313
分類程式碼代碼:
12352200
PubChem物質ID:
24278062
NACRES:
NA.77

product name

Naltrindole hydrochloride, solid

形狀

solid

儲存條件

desiccated

顏色

off-white

溶解度

methanol: 4.5 mg/mL
H2O: 8 mg/mL

儲存溫度

−20°C

SMILES 字串

Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8

InChI

1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1

InChI 密鑰

KNJKRQXCFJCQHC-IDRHMUJXSA-N

基因資訊

human ... OPRD1(4985)

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生化／生理作用

Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.

特點和優勢

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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W Bilecki et al.
European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term
J L Nano et al.
Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)
Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
P S Portoghese et al.
European journal of pharmacology, 146(1), 185-186 (1988-01-27)

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