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种属反应性
mouse
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.4 ng/mL
standard curve range: 0.416-100 ng/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Tyro3(22174)
一般描述
The antibody pair provided in this kit recognizes mouse Tyro3.
应用
请参考Protocol了解详情。
生化/生理作用
Tyrosine-protein kinase receptor (TYRO3) is a transmembrane tyrosine kinase receptor. It plays a significant role in the brain development during embryogenesis. It plays an important role in apoptotic cell clearance. In hepatocellular carcinoma, it is associated with tumor growth, aggressiveness and liver dysfunction. Mutations in the TYRO3 gene intronic regions are linked with asthma. TYRO3 is also a suppressor of type 2 immunity. As part of the TAM (TYRO3, AXL and MER receptors) family, it is activated by PROS1 (protein S) and GAS6 (growth arrest-specific gene 6). Changes in the expression of TYRO3 are linked with the proliferation and survival of cancer cells. Absence of TYRO3 in mice results in neurological disorders.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression.
Duan Y
International Journal of Oncology, 48, 358-366 (2016)
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.
Chan PY
Science, 352, 99-103 (2016)
The Gas6/TAM System and Multiple Sclerosis.
Bellan M, et al.
International Journal of Molecular Sciences, 17 (2016)
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.
Tsou WI
The Journal of Biological Chemistry, 289, 25750-25763 (2014)
Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in juvenile-onset systemic lupus erythematosus.
Ballantine L, et al.
Pediatric Rheumatology Online Journal (2015)
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