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P9564

Sigma-Aldrich

Phleomycin

from Streptomyces verticillus, powder, DNA replication inhibitor

别名:

FT-0697305

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About This Item

CAS号:
11006-33-0
MDL编号:
MFCD00131846
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

Phleomycin from Streptomyces verticillus, powder

表单

powder

质量水平

200

保质期

2 yr

颜色

blue

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes

储存温度

2-8°C

InChI

1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

InChI key

QRBLKGHRWFGINE-UGWAGOLRSA-N

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相关类别

一般描述

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.

应用

Phleomycin from Streptomyces verticillus has been used as an antibiotic in the screening of transformants of Trypanosoma brucei. It has also been used as an antibiotic in the maintenance of Escherichia coli.

生化/生理作用

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000435261
0000435261
0000406625
0000406624
0000397390

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M J Sleigh et al.
Mutation research, 42(2), 181-190 (1977-02-01)
Sulphydryl-mediated DNA breakage, which is induced by the antibiotic phleomycin in vitro, has been found to contribute significantly to the DNA damage produced by phleomycin in Escherichia coli. The effect of pleomycin was inhibited in vivo, as in vitro, by
James B Wilson et al.
Mutation research, 689(1-2), 12-20 (2010-05-11)
The Fanconi anaemia (FA) FANCG protein is an integral component of the FA nuclear core complex that is required for monoubiquitylation of FANCD2. FANCG is also part of another protein complex termed D1-D2-G-X3 that contains FANCD2 and the homologous recombination
C H He et al.
Canadian journal of microbiology, 42(12), 1263-1266 (1996-12-01)
The antibiotic bleomycin is used as an anticancer agent for treating a variety of tumours. The antitumour effect of bleomycin is related to its ability to produce lesions such as apurinic/apyrimidinic sites and single- and double-strand breaks in the cellular
Appolinaire Djikeng et al.
Methods in molecular biology (Clifton, N.J.), 265, 73-83 (2004-04-23)
Trypanosoma brucei, a flagellate protozoa of the family Trypanosomatidae, has become one of the model systems for unicellular pathogens to study fundamentally important biological phenomena. Currently, the method of choice to examine gene function in these organisms is RNA interference
L F Povirk et al.
Biochemistry, 20(3), 665-671 (1981-02-03)
The kinetics and mechanism of binding of Cu-(II).bleomycin, Fe(III).bleomycin, and Cu(II).phleomycin to DNA were studied by using fluorometry, equilibrium dialysis, electric dichroism, and temperature-jump and stopped-flow spectrophotometry. The affinity of Cu(II).bleomycin for DNA was greater than that of metal-free bleomycin
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