PLA0016
Rabbit anti-MDC1 Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
别名:
Em:AB023051.5, KIAA0170, NFBD1, homologue to Drosophila photoreceptor protein calphotin, mediator of DNA-damage checkpoint 1, nuclear factor with BRCT domains 1
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
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生物源
rabbit
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
等級
Powered by Bethyl Laboratories, Inc.
物種活性
human
技術
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2000-1:10000
登錄號
NP_055456.1
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
基因資訊
rabbit ... MDC1(9656)
免疫原
The epitope recognized by PLA0016 maps to a region between residues 475 and 525 of human Mediator of DNA Damage Checkpoint 1 using the numbering given in entry NP_055456.1 (GeneID 9656).
外觀
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
其他說明
MDC1 is required for the S- and G2/M-checkpoint-mediated cell cycle arrest in response to DNA damage. MDC1 interacts with H2AX near sites of DNA double-strand breaks and recruits ATM kinase to foci of DNA damage. MDC1 also appears to regulate the function of other proteins involved in the DNA damage checkpoint such as BRCA1 and Chk2.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Joshua T Burgess et al.
Nucleic acids research, 49(6), 3294-3307 (2021-03-05)
DNA repair pathways are essential to maintain the integrity of the genome and prevent cell death and tumourigenesis. Here, we show that the Barrier-to-Autointegration Factor (Banf1) protein has a role in the repair of DNA double-strand breaks. Banf1 is characterized
Amila Suraweera et al.
Communications biology, 4(1), 484-484 (2021-04-21)
Genomic stability is critical for normal cellular function and its deregulation is a universal hallmark of cancer. Here we outline a previously undescribed role of COMMD4 in maintaining genomic stability, by regulation of chromatin remodelling at sites of DNA double-strand
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