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P7340

(±)-苏-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇盐酸盐

Name: (±)-<I>苏</I>-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇 盐酸盐
Brand: SIGMA

别名:

(±)-苏-PDMP 盐酸盐, PDMP 盐酸盐

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About This Item

经验公式（希尔记法）:

C₂₃H₃₈N₂O₃·HCl

CAS号:

80938-69-8

分子量:

427.02

MDL编号:

MFCD00236490

UNSPSC代码:

12352200

PubChem化学物质编号:

24278649

NACRES:

NA.77

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P4194

DL-苏式-1-苯基-2-棕榈酰氨基-3-吗啉-1-丙醇

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3,3′,5-三碘-L-甲状腺氨酸钠盐

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5.38285

Glucosylceramide Synthase Inhibitor, Genz-123346

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亚硒酸钠

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β-雌二醇

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T2877

3,3′,5-三碘代-L-甲状腺原氨酸

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P8783

黄体酮

Sigma-Aldrich

P0503

O-磷酸乙醇胺

生物来源

synthetic (organic)

质量水平

100

方案

≥98% (TLC)

表单

powder

溶解性

water: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

Cl.CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2

InChI

1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1

InChI key

HVJHJOYQTSEKPK-BLDCTAJRSA-N

生化/生理作用

葡萄糖神经酰胺合成酶抑制剂；阻止由神经酰胺形成葡萄糖基神经酰胺。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells.

A A Weber et al.

British journal of pharmacology, 123(5), 906-910 (1998-04-16)

1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC)

Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells.

J Inokuchi et al.

Journal of cellular physiology, 141(3), 573-583 (1989-12-01)

Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the levels of GlcCer and lactosylceramide (LacCer). The content of ganglioside GM3 was little affected, but the ability to bind a

Radin, et al.

Journal of Lipid Research, 26, 183-213 (1993)

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

Jorge F Haller et al.

Journal of lipid research, 55(3), 493-503 (2013-12-03)

ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid

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