推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
mouse, human, rat
技術
western blot: 1:200 using rat glioma C6 and human neuroblastoma SH-SY5Y cell lines
western blot: 1:400 using recombinant mouse proBDNF
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BDNF(627)
mouse ... Bdnf(12064)
rat ... Bdnf(24225)
一般說明
不会与 pro-NGF、pro-NT-3 或成熟的 BDNF 发生交叉反应。
脑源性神经营养因子（BDNF）基因定位于人类染色体 11p14.1 上。该基因编码前体蛋白proBDNF。成熟的BDNF（mBDNF）是通过proBDNF的翻译后切割合成的。不会与 pro-NGF、pro-NT-3 或成熟的 BDNF 发生交叉反应。
免疫原
对应于人 BDNF（前体）氨基酸残基 72-88 的多肽。该序列的 16/17 残基在小鼠和大鼠中是相同的。
應用
成功使用该抗体的应用以及相关的同行评审论文如下所示。
免疫荧光分析（1篇论文）
免疫荧光分析（1篇论文）
生化／生理作用
脑源性神经营养因子（BDNF）属于分泌蛋白神经营养因子家族。神经营养因子被合成为前神经营养因子（preproneurotrophin ）前体，并被进一步转化为促神经营养因子（proneurotrophin），然后转化为神经营养因子。BDNF在发育中的和成熟的大脑中表达。BDNF的影响是通过与TrkB受体和p75NTR受体结合进行调节。BDNF促进的下游途径包括PI3K、MAPK 和 JAK/STAT。BDNF最重要的作用是调节突触传递和可塑性、蛋白质合成和局部蛋白质磷酸化。
外觀
从含有 1％ 牛血清白蛋白和 ≤0.1% 叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Not finding the right product?
Try our 产品选型工具.
推薦
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Guiping Xu et al.
Translational neuroscience, 13(1), 430-439 (2022-12-24)
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. Esketamine is
11p14. 1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Shinawi M, et al.
American Journal of Medical Genetics. Part A, 155(6), 1272-1280 (2011)
Li Duan et al.
PloS one, 8(9), e73768-e73768 (2013-09-17)
While aberrant activation of microglial cells was evidently involved in neuroinflammation and neurotoxicity in the neurodegenerative diseases such as Alzheimer's and Parkinson's disease, objective of study was to address if activated microglias deliver their effect by releasing pro-neurotrophins. By in
Hui Qiao et al.
Brain research, 1663, 29-37 (2017-03-13)
Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays an important role in the structural plasticity induced by depression. Considering the
Hai-Yang Zhang et al.
Asian journal of andrology, 13(2), 231-235 (2010-12-21)
Retroperitoneal operations, such as radical prostatectomy, often damage the cavernous nerve, resulting in a high incidence of erectile dysfunction. Although improved nerve-sparing techniques have reduced the incidence of nerve injury, and the administration of phosphodiesterase type 5 inhibitors has revolutionized
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门