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Merck
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主要文件

O1012

Sigma-Aldrich

油酰辅酶 A 锂盐

≥90% (HPLC)

别名:

顺式 -9-十八烯酰辅酶A

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About This Item

经验公式（希尔记法）:
C39H68N7O17P3S
CAS号:
188824-37-5
分子量:
1031.98
UNSPSC代码:
41106305
NACRES:
NA.51

方案

≥90% (HPLC)

表单

powder

溶解性

H2O: soluble-50 mg/mL, clear, colorless

储存温度

−20°C

相关类别

应用

辅酶 A 作为酰基载体，乙酰辅酶 A 发挥作用。油酰辅酶 A 可能用于研究酰基辅酶 A：胆固醇酰基转移酶 1 (ACAT1) 等酶参与长链脂肪酸胆固醇酯化的特异性和动力学。

生化/生理作用

油酰辅酶A是一种重要的底物，对于1-烷基-2,3-二酰甘油（ADG）和哈德氏腺（HG）1-烷基-2,3-二酰甘油的超长链单不饱和脂肪酸的生物合成至关重要。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
089K5064V
089K5064
114K70211
116K7025
038K5057

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Catherine C Y Chang et al.
Biochemistry, 49(46), 9957-9963 (2010-10-23)
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane-bound enzyme utilizing long-chain fatty acyl-coenzyme A and cholesterol to form cholesteryl esters and coenzyme A. Previously, we had expressed tagged human ACAT1 (hACAT1) in CHO cells and purified it to homogeneity; however
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2, 3-diacylglycerol
Miyazaki M, et al.
The Journal of Biological Chemistry, 276(42), 39455-39461 (2001)
Chengcheng Guan et al.
Nature communications, 11(1), 2478-2478 (2020-05-20)
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage. SOAT1 is a target to treat several
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.
Leon C, Hill JS, Wasan KM.
Pharmaceut. Res., 22, 1578-1588 (2005)
Mariana Igoillo-Esteve et al.
International journal for parasitology, 41(3-4), 429-438 (2010-12-18)
Metabolism in trypanosomatids is compartmentalised with major pathways, notably glycolysis, present in peroxisome-like organelles called glycosomes. To date, little information is available about the transport of metabolites through the glycosomal membrane. Previously, three ATP-binding cassette (ABC) transporters, called GAT1-3 for
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