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Merck

O6877

Sigma-Aldrich

Octanoyl coenzyme A 锂盐 水合物

≥95% (HPLC)

别名:

Capryloyl coenzyme A 锂盐 水合物

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About This Item

经验公式(希尔记法):
C29H50N7O17P3S · xLi+ · yH2O
分子量:
893.73 (free acid basis)
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

化驗

≥95% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

[Li+].[Li+].[Li+].O.CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23

InChI

1S/C29H50N7O17P3S.3Li.H2O/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36;;;;/h16-18,22-24,28,39-40H,4-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44);;;;1H2/q;3*+1;/p-3/t18-,22-,23-,24+,28-;;;;/m1..../s1

InChI 密鑰

VWXPWBSHKDXAFH-SMMZWZJBSA-K

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應用

辅酶 A 作为酰基载体,乙酰辅酶 A 发挥作用。辛酰辅酶 A 是 饥饿素O-酰基转移酶 (s)(山羊)对饥饿素和其他肽进行酰化(辛酰化)的供体分子。

生化/生理作用

与辅酶 A 共价连接的中链脂肪酸。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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The expression of ghrelin O-acyltransferase (GOAT) in human tissues.
Lim CT, Kola B, Grossman A, Korbonits M.
Endocrine J., 58, 707-710 (2011)
Amparo Romero et al.
European journal of endocrinology, 163(1), 1-8 (2010-04-28)
The ghrelin-ghrelin receptor system is one of the most important mechanisms regulating energy balance and metabolism. Among other actions, central and peripheral administration of ghrelin increases food intake and adiposity. During the last years, many efforts have been made in
Jesus A Gutierrez et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(17), 6320-6325 (2008-04-30)
The peptide hormone ghrelin is the only known protein modified with an O-linked octanoyl side group, which occurs on its third serine residue. This modification is crucial for ghrelin's physiological effects including regulation of feeding, adiposity, and insulin secretion. Despite
Tomoko Takahashi et al.
Journal of biochemistry, 146(5), 675-682 (2009-07-25)
Ghrelin was originally isolated from rat stomach as an endogenous ligand for the GH secretagogue receptor. The major active form of ghrelin is a 28-amino acid peptide modified by an n-octanoic acid on the serine 3 residue, and this lipid
Jing Yang et al.
Cell, 132(3), 387-396 (2008-02-13)
Ghrelin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-deprived stomach. Serine-3 of ghrelin is acylated with an eight-carbon fatty acid, octanoate, which is required for its endocrine actions. Here, we identify GOAT (Ghrelin O-Acyltransferase), a polytopic

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