推荐产品
形狀
powder
品質等級
抗生素活性譜
parasites
作用方式
enzyme | inhibits
SMILES 字串
Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI
1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI 密鑰
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
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應用
氯硝柳胺是驱虫药系列中的特尼酰胺。它能帮助感染人有效对抗绦虫。氯硝柳胺用于研究Wnt / Frizzled-1信号传导途径。它用于抑制NF-κB转录和DNA结合，并提高ROS水平，诱导急性髓性白血病（AML）细胞凋亡。
生化／生理作用
氯硝柳胺解偶联绦虫氧化磷酸化，抑制寄生蠕虫线粒体氧化磷酸化。它阻断肿瘤坏死因子诱导的 IκBα 磷酸化、p65 的转位和 AML 细胞中 NF-κβ 调节基因的表达。
其他說明
50g及250g
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Yanli Jin et al.
Cancer research, 70(6), 2516-2527 (2010-03-11)
NF-kappaB may be a potential therapeutic target for acute myelogenous leukemia (AML) because NF-kappaB activation is found in primitive human AML blast cells. In this report, we initially discovered that the potent antineoplastic effect of niclosamide, a Food and Drug
Mechanism of action of reagents that uncouple oxidative phosphorylation.
E C Weinbach et al.
Nature, 221(5185), 1016-1018 (1969-03-15)
Yi-Te Yo et al.
Molecular cancer therapeutics, 11(8), 1703-1712 (2012-05-12)
A recent hypothesis for cancer chemoresistance posits that cytotoxic survival of a subpopulation of tumor progenitors drives the propagation of recurrent disease, underscoring the need for new therapeutics that target such primitive cells. To discover such novel compounds active against
Jing-Xuan Pan et al.
Chinese journal of cancer, 31(4), 178-184 (2012-01-13)
Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also
Jones Gyamfi et al.
Scientific reports, 9(1), 11336-11336 (2019-08-07)
The microenvironment of breast cancer comprises predominantly of adipocytes. Adipocytes drive cancer progression through the secretion adipocytokines. Adipocytes induce epithelial mesenchymal transition of breast cancer cells through paracrine IL-6/Stat3 signalling. Treatment approaches that can target adipocytes in the microenvironment and
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