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Merck
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文件

S9192

Sigma-Aldrich

Ser-Leu-Ile-Gly-Lys-Val-amide

≥95% (HPLC), solid

别名:

PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2

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About This Item

经验公式（希尔记法）:
C28H54N8O7
CAS号:
190383-13-2
分子量:
614.78
MDL號碼:
MFCD02259590
分類程式碼代碼:
12352200
PubChem物質ID:
329824618
NACRES:
NA.32

品質等級

200

化驗

≥95% (HPLC)

形狀

solid

UniProt登錄號

Q9WTL4

儲存溫度

−20°C

SMILES 字串

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1

InChI 密鑰

HOWDUIVVWDUEED-WAUHAFJUSA-N

基因資訊

mouse ... Insrr(23920)

Amino Acid Sequence

Ser-Leu-Ile-Gly-Lys-Val-NH2

生化／生理作用

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.
Proteinase-activated receptor-2 (PAR2)-activating peptide.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

其他說明

Lyophilized from 0.1% TFA in H2O

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Hendrik Ungefroren et al.
Molecular pharmacology, 92(5), 519-532 (2017-08-27)
Transforming growth factor-
Kaushik Das et al.
Scientific reports, 8(1), 7357-7357 (2018-05-11)
Metastasis, the hallmark of cancer propagation is attributed by the modification of phenotypic/functional behavior of cells to break attachment and migrate to distant body parts. Cancer cell-secreted microvesicles (MVs) contribute immensely in disease propagation. These nano-vesicles, generated from plasma membrane
D Quanjun et al.
European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)
Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)
Abhishek Roy et al.
The Journal of biological chemistry, 292(33), 13688-13701 (2017-05-20)
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either
Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
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