推荐产品
方案
≥98% (HPLC)
表单
powder
溶解性
1 M NaOH: 20 mg/mL, clear to slightly hazy
SMILES字符串
CN1C(=O)NC2=C(NC(=O)N2)C1=O
InChI
1S/C6H6N4O3/c1-10-4(11)2-3(9-6(10)13)8-5(12)7-2/h1H3,(H,9,13)(H2,7,8,12)
InChI key
QFDRTQONISXGJA-UHFFFAOYSA-N
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应用
1-甲基尿酸已用于：
- 通过液相色谱和串联质谱法测定粪便样品中的尿酸
- 合成尿液样品的比浊法
- 作为CYP1A2（细胞色素P450家族1亚家族A成员2）测定的底物
生化/生理作用
1-甲基尿酸（1-U）是咖啡因和茶碱的主要代谢产物，具有抗氧化活性，可保护诸如低密度脂蛋白（LDL）之类的分子免受氧化修饰。1-甲基尿酸可用于旨在区分咖啡因和茶碱代谢物活性的研究。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9
DeBosch BJ, et al.
Nature Communications, 5, 4642-4642 (2014)
C Lee
Clinica chimica acta; international journal of clinical chemistry, 295(1-2), 141-154 (2000-04-18)
Although caffeine has been suggested as an antioxidant at millimolar concentrations, little information is available about the antioxidant activity of caffeine and its metabolites at physiological concentrations. Antioxidant activity was measured by oxygen-radical absorbing capacity (ORAC) using 2, 2'-azobis(2-amidinopropane) dihydrochloride
Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers
Begas E, et al.
Food And Chemical Toxicology, 100, 80-89 (2017)
Theophano A Psarra et al.
Fundamental & clinical pharmacology, 22(5), 537-547 (2008-10-11)
The present study, aimed to clarify whether the gastrointestinal adverse effects following administration of the bronchodilator theophylline are owing to the action of the drug itself or its metabolites, investigates the pharmacodymanic effects of theophylline's metabolites on the spontaneous contractility
Improved HPLC assay for measuring serum vitamin C with 1-methyluric acid used as an electrochemically active internal standard.
Leslie F McCoy et al.
Clinical chemistry, 51(6), 1062-1064 (2005-04-30)
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