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Merck
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文件

M4765

Sigma-Aldrich

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺

elastase substrate, chromogenic, ≥98% (HPLC), powder

别名:

N-（甲氧基琥珀酰基）-L-丙氨酰-L-丙氨酰-L-脯氨酰-L-缬氨酸4-硝基苯胺, N-（甲氧基琥珀酰基）-Ala-Ala-Pro-Val 4-硝基苯胺

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About This Item

经验公式（希尔记法）:
C27H38N6O9
CAS号:
70967-90-7
分子量:
590.63
Beilstein:
6266359
MDL號碼:
MFCD00077137
分類程式碼代碼:
12352204
PubChem物質ID:
24896943
NACRES:
NA.32

product name

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺, elastase substrate

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMF: soluble 25 mg/mL, clear, colorless to light yellow

儲存溫度

−20°C

SMILES 字串

[H][C@]1(CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C27H38N6O9/c1-15(2)23(26(38)30-18-8-10-19(11-9-18)33(40)41)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,30,38)(H,31,37)/t16-,17-,20-,23-/m0/s1

InChI 密鑰

VLVGCNNWNUERRZ-OSAZLGQLSA-N

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應用

MeO-SucAAPVpNA已用于测量嗜中性粒细胞弹性蛋白酶活性：
  • 人和小鼠嗜中性粒细胞体外补充锌补充造成的结果
  • 确定老化嗜中性粒细胞的功能特性，以评估它们在促进肿瘤转移方面的作用
  • 确定伯尔硬胡桃（Sclerocarya birrea (A. Rich.)）的抗弹性蛋白酶作用Hochst

生化／生理作用

人类白细胞弹性蛋白酶 (HLE) 是一种丝氨酸蛋白酶，与炎症和组织退化相关。它是最具破坏性的蛋白酶之一，其在肺气肿进程中的作用得到了广泛研究。这种肽酶可被HLE及不同物种和细胞的其他弹性蛋白酶选择性水解。弹性蛋白酶样蛋白酶切割MeO-SucAPVVpNA对于肿瘤坏死因子-α (TNF-α)和白细胞介素-1α (IL-1α)诱导的血小板活化因子(PAF)合成至关重要。由于释放4-硝基苯胺，底物的酶促水解速率随着吸光度增加。通常在400 nm或更高波长处测量吸光度。

基底

人白细胞弹性蛋白酶的底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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S C Wright et al.
Cancer research, 58(23), 5570-5576 (1998-12-16)
Studies on the mechanism of apoptosis in this laboratory support a model in which signal transduction involving caspase 3 leads to activation of a serine protease called Mr 24,000 apoptotic protease (AP24), which then induces internucleosomal DNA fragmentation in the
Anna G Drannik et al.
PloS one, 7(4), e35866-e35866 (2012-05-01)
Upon viral recognition, innate and adaptive antiviral immune responses are initiated by genital epithelial cells (ECs) to eradicate or contain viral infection. Such responses, however, are often accompanied by inflammation that contributes to acquisition and progression of sexually transmitted infections
N P Rodis et al.
Journal of enzyme inhibition, 16(2), 95-105 (2001-05-09)
A series of novel low molecular weight thiocarbamate esters (1e-6e) were synthesized and evaluated as inhibitors of human leukocyte elastase (HLE). The thiocarbamate esters studied consist of a substituted primary or secondary aliphatic or aromatic amine and a 1-phenyl-1H-tetrazole-5-thiol (Table
Rendong Fang et al.
Mucosal immunology, 12(5), 1092-1103 (2019-07-07)
It is widely accepted that inflammasomes protect the host from microbial pathogens by inducing inflammatory responses through caspase-1 activation. Here, we show that the inflammasome components ASC and NLRP3 are required for resistance to pneumococcal pneumonia, whereas caspase-1 and caspase-11
High-throughput protein crystallography and drug discovery
Tickle I, et al.
Chemical Society Reviews, 33, 558-565 (2004)
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