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生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
9E10, monoclonal
形狀
buffered aqueous solution
分子量
62 kDa
物種活性
human
濃度
~2 mg/mL
技術
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:5000 using c-myc tagged fusion protein
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... MYC(4609)
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一般說明
V-Myc（v-myc禽髓细胞瘤病病毒致癌基因同源物）是一种转录因子，其由MYC基因编码。它最初被描述为禽逆转录病毒致癌基因的同源物。它属于转录因子家族，以碱性区螺旋-环-螺旋/亮氨酸拉链为特征。它与N-Myc和L-Myc一起构成原癌基因家族。它与MAX形成异二聚体，该二聚体与DNA上的E-boxes/CACGTG基序相结合。该基因位于人染色体8q24上。
小鼠抗c-Myc单克隆抗体可识别位于人类致癌基因c-myc产物序列(EQKLISEEDL)内的表位。
免疫原
人p62c-Myc蛋白的合成肽。
應用
小鼠产生的单克隆抗c-Myc抗体适用于免疫沉淀、 免疫印迹、 酶联免疫吸附分析（ELISA）、免疫荧光、 微阵列和电子显微。它也被应用于ChIP（染色质免疫沉淀）。
生化／生理作用
V-myc禽髓细胞瘤病病毒致癌基因同源物属于MYC家族。当这些蛋白过表达时，可导致DNA双链断裂(DSBs)和基因组不稳定。转录因子MYC有助于调节长链非编码RNA(lncRNAs)，后者与癌细胞增殖和肿瘤发生有关。它的过表达也与各种癌症有关，尤其是B细胞淋巴瘤。c-MYC表达的增加对B细胞淋巴瘤向CD4+ T细胞功能表达Ags/肽的能力有负面影响。该蛋白在Ag表达的几个关键点发挥抑制作用。它与Burkitt淋巴瘤和一组弥漫性巨大B细胞淋巴瘤(DLBCL)有关。
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
準備報告
工作稀释液：1：5000
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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